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Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury.

Title Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury.
Publication Type Journal Article
Year of Publication 2013
Authors Williams, Shawniqua T. , Conte Mary M. , Goldfine Andrew M. , Noirhomme Quentin , Gosseries Olivia , Thonnard Marie , Beattie Bradley , Hersh Jennifer , Katz Douglas I. , Victor Jonathan D. , Laureys Steven , and Schiff Nicholas D.
Journal Elife
Volume 2
Pagination e01157
Date Published 2013
ISSN 2050-084X
Abstract

Zolpidem produces paradoxical recovery of speech, cognitive and motor functions in select subjects with severe brain injury but underlying mechanisms remain unknown. In three diverse patients with known zolpidem responses we identify a distinctive pattern of EEG dynamics that suggests a mechanistic model. In the absence of zolpidem, all subjects show a strong low frequency oscillatory peak ∼6-10 Hz in the EEG power spectrum most prominent over frontocentral regions and with high coherence (∼0.7-0.8) within and between hemispheres. Zolpidem administration sharply reduces EEG power and coherence at these low frequencies. The ∼6-10 Hz activity is proposed to arise from intrinsic membrane properties of pyramidal neurons that are passively entrained across the cortex by locally-generated spontaneous activity. Activation by zolpidem is proposed to arise from a combination of initial direct drug effects on cortical, striatal, and thalamic populations and further activation of underactive brain regions induced by restoration of cognitively-mediated behaviors. DOI: http://dx.doi.org/10.7554/eLife.01157.001 .

DOI
Alternate Journal Elife
PubMed ID
PubMed Central ID PMC3833342

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